Medicinal mushrooms benefit human health, by optimizing immune health and reducing inflammation. They show clinical efficacy in treating various cancers, cardiovascular and respiratory issues, diabetes, hepatitis, kidney disease, and numerous auto-immune conditions. Forward thinking herbalists, MDs, oncologists and pharmacists would like to use medicinal mushrooms, but are looking for proof. Human clinical studies from the scientific and medical journals suggest medicinal mushrooms may be effective. For a wide range of life-threatening conditions, including numerous "gold standard" double-blind, placebo-controlled, randomized human clinical trial publications. Both fruiting body and mycelium products show efficacy in improving quality of life during chemotherapy or radiation, as well as prolonged survival rates.